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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
STXBP1
All Species:
42.12
Human Site:
S146
Identified Species:
66.19
UniProt:
P61764
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P61764
NP_001027392.1
594
67569
S146
P
Y
E
S
Q
V
Y
S
L
D
S
A
D
S
F
Chimpanzee
Pan troglodytes
XP_001152683
595
67000
V146
P
Y
E
A
Q
V
R
V
F
S
L
D
A
P
H
Rhesus Macaque
Macaca mulatta
XP_001095617
580
66142
S132
P
Y
E
S
Q
V
Y
S
L
D
S
A
D
S
F
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q64324
593
66339
S146
P
Y
E
A
Q
V
F
S
L
D
A
P
H
S
T
Rat
Rattus norvegicus
P61765
594
67550
S146
P
Y
E
S
Q
V
Y
S
L
D
S
A
D
S
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508183
589
67400
S132
P
Y
E
S
Q
V
Y
S
L
D
S
A
D
S
F
Chicken
Gallus gallus
Q6R748
594
67454
S146
P
S
E
S
Q
V
Y
S
L
D
S
A
D
S
F
Frog
Xenopus laevis
NP_001093335
595
67691
S146
P
Y
E
S
Q
V
F
S
L
D
Y
P
D
S
F
Zebra Danio
Brachydanio rerio
NP_001020353
591
67111
S146
P
Y
E
S
Q
V
F
S
L
D
N
P
D
A
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07327
597
67832
S157
P
Y
E
C
Q
V
F
S
L
D
S
P
D
T
F
Honey Bee
Apis mellifera
XP_396375
585
66573
S146
P
Y
E
S
Q
V
F
S
L
D
S
A
E
T
F
Nematode Worm
Caenorhab. elegans
P34815
673
76715
N226
P
Y
E
S
Q
V
F
N
L
D
S
P
D
T
F
Sea Urchin
Strong. purpuratus
NP_999834
593
68046
S143
P
Y
E
S
Q
V
F
S
L
D
C
P
D
S
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SZ77
662
75299
V161
S
M
D
I
Q
G
F
V
T
N
N
E
N
A
L
Baker's Yeast
Sacchar. cerevisiae
P30619
724
83462
E144
V
K
E
S
Q
F
F
E
T
L
Q
M
E
H
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
63.8
97.6
N.A.
N.A.
62.7
100
N.A.
93.4
97.9
92.4
86.5
N.A.
63.4
63.9
52.1
60.9
Protein Similarity:
100
81.1
97.6
N.A.
N.A.
80.6
100
N.A.
96.1
99.4
97.9
94.6
N.A.
78
79.6
67.4
77.7
P-Site Identity:
100
33.3
100
N.A.
N.A.
60
100
N.A.
100
93.3
80
73.3
N.A.
73.3
80
73.3
80
P-Site Similarity:
100
40
100
N.A.
N.A.
80
100
N.A.
100
93.3
86.6
93.3
N.A.
86.6
100
93.3
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.2
22.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.2
42.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
14
0
0
0
0
0
0
7
40
7
14
0
% A
% Cys:
0
0
0
7
0
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
0
0
7
0
0
0
0
0
0
80
0
7
67
0
0
% D
% Glu:
0
0
94
0
0
0
0
7
0
0
0
7
14
0
0
% E
% Phe:
0
0
0
0
0
7
60
0
7
0
0
0
0
0
74
% F
% Gly:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
7
7
7
% H
% Ile:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
80
7
7
0
0
0
7
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
7
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
7
0
7
14
0
7
0
0
% N
% Pro:
87
0
0
0
0
0
0
0
0
0
0
40
0
7
0
% P
% Gln:
0
0
0
0
100
0
0
0
0
0
7
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% R
% Ser:
7
7
0
74
0
0
0
74
0
7
54
0
0
54
7
% S
% Thr:
0
0
0
0
0
0
0
0
14
0
0
0
0
20
7
% T
% Val:
7
0
0
0
0
87
0
14
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
80
0
0
0
0
34
0
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _